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SOURCE Replikins, Ltd.
Anti-Mers-CoV Synthetic Replikins Vaccine™ Available Now to Vaccinate Camels
LONDON, May 16, 2014 /PRNewswire/ -- A Replikins analysis by Bioradar, Ltd of Mers-CoV in all isolates of the virus genes reported to date in Pubmed from both humans and camels has revealed specific shared gene Replikin structures that are not just homologous but are identical in the virus genes infecting both camels and humans, and conserved since 2012 in cases from all countries affected. Replikins, Ltd. has now produced a Replikins Synthetic Vaccine based on these identical shared structures. This vaccine, constructed like the vaccine shown effective in the case of H5N1, is offered as a potential inhibitor of the progression of Mers-CoV. The Anti-Mers-CoV vaccine is now available for camels, and if safe and effective, for humans.
Mers' related coronavirus, SARS, produced approximately 8000 human cases and 800 deaths in 2003. Mers has a higher mortality rate than SARS. Mers started in 2012 with an approximate mortality rate of 40%, and now the mortality rate is approximately 30%. The duration of the Mers outbreak is also greater than that of SARS. SARS' abrupt rise and rapid decline in gene Replikin Count signaled in 2002 that the 2003 outbreak would occur but would be over soon (and it was over within one year)(1,5). In contrast, the increased Replikin Count reported in October 2013 (1) was followed by the upsurge in Mers human outbreaks in 2014, and indicates a more prolonged course and a greater risk of pandemic. No anti-Mers vaccine has been available.
The Anti-Mers-CoV Replikins Synthetic Vaccine, the only one available now, is unique because:
Replikins therefore provide a complete defense system, not previously available, beginning with prediction pre-outbreak, based on detection and specific identification of the quantitative specific gene changes associated with rapid replication. These gene changes can be addressed in advance of, or after, outbreaks occur, providing time to possibly prevent pandemics rather than just reacting to them.
While it would have been preferable to begin testing the Replikins Anti-Mers vaccine when the upturn in gene Replikin Count was noted in October 2013 (1), there still may be time to reduce or interrupt the present progression of Mers-CoV. Camels have been hypothesized to be a reservoir and source of human Mers infection mostly because of the detection in camels of antibodies which react with the Mers-CoV virus (2-4). The present quantitative gene-specific structural findings support this hypothesis. The Replikins Anti-Mers-CoV Vaccine, now available, can be tested and used first in camels in Saudi Arabia to strengthen their immune response to Mers-CoV and to reduce the risk of passing this infection to humans.
Contact: Email, Tel 646-320-5910
1.MERS WATCH BBC October 21, 2013
2.CIDRAP NEWS. Reports: Mers-CoV found in Saudi's patient's camel. Nov. 11, 2013.
3.Memish,Ziad. Promed Mail. Animal reservoirs, camels. http://www.isid.org Nov. 12, 2013.
4.Maged G. et al Mers-CoV in Dromedary Camel Herd, Saudi Araba. EIDjournalAhead of Print / In Press May 15, 2014
5.Bogoch S and Bogoch ES. Nature Precedings doi: 10.1038/npre.2012.6952.1 Replikins Pandemic Prevention: Increase of Strain-Specific Influenza Genomic Replikin Counts, Having Predicted Outbreaks and their Location Seven Times Consecutively, Up to Two Years in Advance, Provides Time for Prevention of Pandemics.
6.Replikins Reports < Replikins > 2006-2014.
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